Comparative Study of Rheological Properties of Gels and Creams on Different Carrier Bases

Introduction . The study of rheological properties (dynamic and plastic viscosity, yield strength, the degree presence a thixotropic effect, nature type flow) are important for development soft dosage forms. These affect stability form during storage, its technological consumer characteristics Aim Study main parameters developed gels creams on various carrier bases. Materials methods Meloxicam as active ingredient excipients: sodium alginate, twin-80, propylene glycol, cremophor, glycerin, essential oils lemon orange, carbopol 980, polyethylene glycol-400 (PEG-400), viburnum bark, chamomile flowers, chlorhexidine bigluconate 20 %, menthol, sorbitol, corn oil, distilled monoglycerides (MHD), cetyl alcohol, coconut salicylic acid, emulsion wax, preparation OS-20, triethanolamine (TEA), euxil PE 9010 were used ex[eroimental samples. Three laboratory samples formulations with mass 100 g each prepared. tested 24 hours after their using Anton Paar DV-2P viscometer (Anton GmbH, Austria), spindle L4. structural mechanical device designed at St. Petersburg State Chemical Pharmaceutical University under thesupervision Professor, Doctor Sciences V. A. Vainshtein. Results discussion greatest was observed sample No. 1 (gel based alginate) 3 (cream). ascending descending hysteresis loop curves indicates that test have properties. Samples 2 upward downward flow superimposed other.This phenomenon is typical all feature. relaxation structure an elastic-plastic material deformation caused by introduction tester stock occurs according to logarithmic law. At rest, when stockis not introduced into material, intact has maximum density (static viscosity). results in forced flow. tension moment reflects strength.Further, immersed devoce, recovery destroyed bonds occurs. Such pattern dynamics resistance structured (non-Newtonian) liquids. Conclusion three experimental made different bases investigated. importance studies drug high e quality shown.